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More than 50 million Americans now suffer from one or more autoimmune illness and 80% are women. Thirty years ago, only one in 400 people developed an autoimmune illness but today, one in 12 Americans and one in nine women are diagnosed with an autoimmune illness. Currently we have 100+ autoimmune disorders all caused by the common thread of autoimmunity.

This module will focus on the adaptive immune system dysregulation and autoimmune disease, inflammaging and metaflammation and drivers of system wide inflammation. We will review a system’s biology approach to assessment and treatment of chronic inflammation that lead to a variety of clinical syndromes such as chronic fatigue, fibromyalgia, rheumatoid arthritis, lupus, and neurodegenerative disorders. Cellular and molecular biology of immunity, the cellular stress response, oxidation, genetic damage, inflammation, etiology of disease including environmental and lifestyle factors, and the risk for cancer development are also reviewed. Additionally, we will review innovative treatment options in autoimmune illness and ways to modulate inflammation with low dose naltrexone as well as other botanicals.


  • Identify the role of the adaptive immune system in autoimmune disease
  • Recognize the intracellular signaling pathways, cellular biology, and molecular biology of immunity and inflammation including the cell danger response and development of chronic inflammatory response syndrome (CIRS)
  • Mast Cell Activation Syndrome: the forgotten side of the immune system
  • Describe the important interactions of metabolic disorders as drivers of inflammation
  • Review innovation in the treatment of rheumatoid arthritis (RA), lupus and inflammatory bowel disease (IBD)
  • Review neurodegenerative disorders and ways to combat them
  • Compare integrative oncology protocols and immune nutrition support techniques
  • Describe the role of resolvins, protectins and other mediators in reversing the inflammatory cascade
  • Describe the role of gut dysregulation and its role in autoimmunity
  • Review the role of low-dose naltrexone in the treatment of autoimmune disorders.
  • Review the role of botanicals and other innovative substances in the treatment of systemic inflammation
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Autoimmune Disease: Adaptive Immune System Review
Thomas Guilliams, PhD
2 hr
How the Gut Microbiota influences Metabolic Resiliency, Immunocompetence and Biotransformation
Thomas Guilliams, PhD
2 hr
Psycho-Neuro-Immunology - The New Frontier
Deborah Simkin, MD
2 hr
Hormonal Effects on Immune Regulation and Ways to Balance
Felice Gersh, MD
2 hr
Metaflammation: A System’s Biology Approach
James LaValle, RPh, CCN
2 hr
Combating Neurodegeneration with Focus on MS
Terry Wahls, MD
2 hr
RA, Osteoarthritis, Lupus and All Autoimmune
Aly Cohen, MD
2 hr
Cancer- Immune Dysregulation and Novel Treatment Approach
Mark Rosenberg, MD
2 hr
Dental as a Missing Link for Medical Failures: Lyme, Cancer, Neurologic Disorder and More
Simon Yu, MD
2 hr
Herbals/Supplements in Immune Modulation
Sahar Swidan, PharmD, BCPS, FMNM, ABAAHP
1 hr
Immunomodulatory Supplements and Peptides: The New Frontier
James LaValle, RPh, CCN
1 hr
Regenerative Therapies in Autoimmune Disorders
Kathleen O’Neil-Smith, MD
2 hr
Low Dose Naltrexone: Exciting Clinical Applications
Sahar Swidan, PharmD, BCPS, FMNM, ABAAHP
1 hr
Patient Cases – Connecting All the Dots
Andrew Heyman, MD, MHSA
1 hr


Clinical Strategies To Optimize Metabolic Resiliency, Immunocompetence And Biotransformation (Part B)
Allied Health