Nitric Oxide Applications For
Clinical Practice

After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. During his tenure as faculty and independent investigator at UT, his research focused on drug discovery through screening natural product libraries for active compounds. His nine years at UT led to several discoveries which have resulted in seven issued US patents and nine pending worldwide. Dr. Bryan has been involved in nitric oxide research for the past 16 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 5 books. He is an international leader in molecular medicine and natural product chemistry.

She combines her talents as an Integrative Physician, specializing in all aspects of female health. She is especially renowned for her expertise in hormonal management of women, and has a unique specialization in PCOS, the most common endocrinopathy of women.

In addition to being a sought-after international speaker and published writer, she works full time as the Medical Director of one of the most successful private practices in Orange County, California: The Integrative Medical Group of Irvine. Her long and distinguished career has also included many years serving as an Assistant Clinical Professor of OB/GYN at the Keck/USC School of Medicine, appearing as a frequent guest lecturer to MD/MBA students at the UCI Paul Merage School of Business, and working as a highly respected forensic expert in gynecological matters. She continues a close affiliation with the Fellowship in Integrative Medicine at the University of Arizona School of Medicine, helping the Fellowship candidates with their comprehensive examinations.

Dr. Gersh has been the recipient of numerous awards, including the being awarded membership in Alpha Omega Alpha-the medical honor society awarded to the top 5 percent of medical students, named the outstanding volunteer faculty for the OB/GYN Department at USC-Keck School of Medicine, identified as a Physician of Excellence for Orange County 13 years in a row and a SuperDoctor of Southern California for the past few years, as well as a TopDoc, among others.

Dr. Gersh has been heard around the world on numerous podcasts and webinars and recently spoke in Australia, New Zealand, and Canada, on various issues of menopause and fertility. She recently also spoke in Dubai - presenting a two day conference on comprehensive medical care for women of all ages. Dr. Gersh is currently working on an innovative book on unique aspects and therapies for women with Polycystic Ovary Syndrome.

Dr Houston was selected as one of the Top Physicians in Hypertension in the US in 2008-2014 by the Consumer Research Council, and by USA Today as one of the Most Influential Doctors in the US in both Hypertension and Hyperlipidemia twice in 2009- 2010. He was selected as The Patient’s Choice Award in 2010 -2012 by Consumer Reports USA. He is triple boarded certified by the American Board of Internal Medicine (ABIM), the American Society of Hypertension (ASH) (FASH) and the American Board of Anti-Aging and Regenerative Medicine (ABAARM, FMNM). He holds two Masters of Science degrees in HUMAN NUTRITION from the University of Bridgeport, CT and another in METABOLIC and NUTRITIONAL MEDICINE (University of South Florida School of Medicine-Tampa). Dr. Houston has presented over 10,000 lectures, nationally and internationally and published over 250 medical articles, scientific abstracts in peer reviewed medical journals , books and book chapters.. He is an author, teacher, clinician and researcher.

Dr. Lefer’s research program at is focused on the investigation of the pathophysiology of acute myocardial infarction and heart failure. Dr. Lefer was one of the pioneers in nitric oxide physiology and pharmacology and among the first to demonstrate the profound cardioprotective actions of nitric oxide based therapies over 20 years ago.  Dr. Lefer’s lab continues to study the use of nitric oxide therapy for cardiovascular disease. Dr. Lefer serves on several NIH Study Sections and has served as a grant reviewer for the American Heart Association (AHA) and the American Diabetes Association (ADA). Dr. Lefer also serves on a number of AHA national committees. Dr. Lefer has authored over 220 original research articles in peer-reviewed journals and has a long-standing track record of research support from the National Institutes of Health (NIH) Heart Lung and Blood Institute.