More than 50 million individuals living within the U.S. now suffer from one or more autoimmune illness and 80% are women. Thirty years ago only one in 400 people developed an autoimmune illness but today one in 12 within the U.S. and one in nine women are diagnosed with an autoimmune illness. Currently, there are 100+ autoimmune disorders all caused by the common thread of autoimmunity. Why the radical change in incidence? Module VI will review the various etiologies of modern-day living that are skyrocketing the incidence of immune and mitochondrial dysregulation and inflammation leading to the clinical manifestations of autoimmune disease, chronic fatigue syndrome, pain, and sleep dysregulation.