Unlock the power of interconnected systems to transform patient care.
Module II of A4M’s Fellowship in Longevity Medicine explores the complex synergy between the gut, brain, metabolic, and cardiovascular systems—offering a comprehensive framework for diagnosing, preventing, and treating chronic conditions at their root.
Key Focus Areas
Cardiovascular Health
- Foundations of Heart Health: Identify the roles of diet, physical activity, and stress regulation in cardiovascular outcomes.
- Risk Reduction: Learn to spot early warning signs and apply preventive strategies.
- Integrative Approaches: Incorporate lifestyle and functional medicine into heart care.
Blood Sugar & Metabolic Health
- Glucose & Insulin Dynamics: Understand the mechanisms of glucose metabolism and insulin sensitivity.
- Lifestyle & Metabolism: Investigate how nutrition, exercise, and stress impact metabolic function.
- Managing Metabolic Syndrome: Prevent and treat insulin resistance, Type 2 diabetes, and related conditions.
Gut Health & Immunity
- The Microbiome & Wellness: Examine how gut microbes influence immune response, inflammation, and chronic disease risk.
- The Gut-Brain Axis: Explore the two-way communication between the GI tract and the brain—linking digestion to mood, memory, and cognition.
- Gastrointestinal Disorders: Learn diagnostic strategies and therapeutic interventions for common GI issues.
Brain Health & Cognition
- Neurobiology of Function: Delve into the cellular and molecular foundations of cognition and emotional health.
- Metabolism & the Mind: Discover the impact of blood sugar and nutrient delivery on brain function.
- Cognitive Longevity: Gain tools for early detection, risk reduction, and enhancement of mental performance.
What You’ll Gain from this Module
- Assess and manage cardiovascular risk using holistic protocols
- Design comprehensive, multi-system care strategies for longevity-focused practice
- Understand the principles of blood sugar regulation and its impact on chronic disease
About the Fellowship in Longevity Medicine
The A4M Fellowship in Longevity Medicine is the world’s premier training program for healthcare professionals committed to extending healthspan, preventing disease, and transforming the future of aging.
Grounded in the latest clinical research and real-world application, the Fellowship provides the knowledge, tools, and credentials to practice cutting-edge, personalized medicine.
Ready to advance your expertise?
Join thousands of practitioners worldwide who are redefining what it means to age well.
Register Now
Schedule
DECEMBER 11, 2026
Vascular Aging & Gut-Heart Axis | Hypertension
Cluster 1 -- Vascular Aging & Gut-Heart-Metabolic Axis
8:00 am
Vascular Aging and Cardiovascular Risk
- Identify major drivers of vascular aging, including inflammation, oxidative stress, and arterial stiffness.
- Explain how vascular aging contributes to cardiovascular disease and reduced healthspan.
- Apply integrative strategies to support vascular resilience and cardiovascular prevention.
Mark Houston, MD, MS, MSc
9:00 am
Break
10:30 am
The Gut-Heart-Metabolic Axis
- Describe how gut health, inflammation, and metabolism influence cardiovascular risk.
- Recognize key biomarkers that connect gut, vascular, and metabolic dysfunction.
- Apply nutrition, microbiome, and lifestyle strategies to support cardiometabolic health.
TBD
11:00 am
Hypertension in Longevity Medicine: Root Causes and Clinical Evaluation
- Describe the vascular, metabolic, neuroendocrine, and inflammatory drivers of hypertension.
- Evaluate hypertensive patients using ambulatory blood pressure monitoring, arterial stiffness, and advanced labs.
- Apply integrative, precision strategies for hypertension prevention and early management.
Mark Houston, MD, MS, MSc
12:00 pm
Lunch Sponsored by KBMO (Non-CME)
Cluster 2 -- Hypertension: Pathophysiology, Management & Risk Reclassification
1:30 pm
Imaging, Endothelial Function, and Risk Reclassification
- Interpret CAC, CCTA, CIMT, and endothelial function testing to refine cardiovascular risk.
- Use advanced imaging and vascular data to reclassify risk and detect subclinical disease.
- Integrate imaging results into shared decision-making and longitudinal care plans.
Joel Kahn, MD, FACC
2:30 pm
Hypertension in Practice: Advanced Management and Case Applications
- Evaluate resistant, white-coat, masked, and secondary hypertension phenotypes.
- Individualize pharmacologic and integrative therapies based on mechanism and biomarker profile.
- Apply integrative strategies to complex hypertension cases for optimal blood pressure control.
Mark Houston, MD, MS, MSc
3:30 pm
Break
4:00 pm
Healthspan: Why Cartilage, Microvasculature, and Inflammation Matter
Kiran Krishnan, PhD
4:30 pm
The Brain-Heart Connection: Inflammation, Stress, and Cardiovascular Risk
- Describe how neuroinflammation, autonomic dysregulation, and stress drive cardiovascular risk.
- Evaluate how depression, anxiety, and chronic stress influence cardiovascular outcomes.
- Design integrative strategies that support both cognitive and cardiovascular health.
TBD
5:30 pm
Hypertension Case Panel: Applying Longevity Principles to Complex HTN Cases
- Apply longevity-focused principles to challenging hypertension cases.
- Integrate imaging, biomarkers, and lifestyle interventions in shared decision-making.
Faculty
6:00 pm
Close of Session
DECEMBER 12, 2026
Dyslipidemia & Advanced Lipidology | Cardiometabolic Pharmacology, Exercise & Nutrition
Cluster 3 -- Dyslipidemia, Advanced Lipidology & Cardiovascular Imaging
8:00 am
Dyslipidemia and Atherosclerosis: Advanced Clinical Management
- Describe the pathophysiology of dyslipidemia-driven atherosclerosis and plaque progression.
- Interpret advanced lipid testing, including ApoB, Lp(a), LDL particle number, and sdLDL.
- Apply integrative, precision strategies that combine nutrition, nutraceuticals, and pharmacotherapy.
Mark Houston, MD, MS, MSc
9:30 am
Break
10:00 am
Advanced Lipids, Imaging, and Plaque Risk
- Evaluate ApoB, Lp(a), LDL particle metrics, and remnant cholesterol as predictors of residual risk.
- Integrate CAC, CCTA, and carotid imaging with advanced lipid data to refine risk classification.
- Develop strategies to support plaque stabilization and regression through combined therapies.
Joel Kahn, MD, FACC
11:00 am
Dyslipidemia in Practice: Cases, Therapies, and Monitoring
- Analyze complex dyslipidemia cases, including statin-intolerant and elevated Lp(a) patients.
- Evaluate emerging lipid-lowering agents such as PCSK9 inhibitors, inclisiran, and bempedoic acid.
- Design longitudinal monitoring plans using advanced lipid biomarkers and imaging endpoints.
Mark Houston, MD, MS, MSc
12:00 pm
Lunch | Car Giveaway in Exhibit Hall
Cluster 4 -- Cardiometabolic Pharmacology, Exercise Medicine & Nutrition
1:30 pm
GLP-1s, SGLT2s, and Cardiovascular Outcomes
- Summarize how GLP-1 and SGLT2 therapies affect cardiovascular and metabolic outcomes.
- Identify patients who may benefit from these therapies in longevity-focused practice.
- Integrate pharmacologic tools with lifestyle, nutrition, and risk-reduction strategies.
TBD
2:30 pm
Exercise as Medicine: VO2 Max, Zone 2, and Cardiac Resilience
- Explain how cardiorespiratory fitness and VO2 max predict cardiovascular and all-cause mortality.
- Differentiate Zone 2 training, HIIT, and resistance exercise by their cardiometabolic adaptations.
- Design individualized exercise prescriptions for high-risk cardiovascular patients.
Joel Jamieson
3:30 pm
Break
4:00 pm
Nutrition Strategies for Cardiovascular Longevity
- Summarize the evidence for Mediterranean, plant-predominant, and low-carbohydrate dietary patterns.
- Evaluate the cardiovascular effects of omega-3s, polyphenols, fiber, and ultra-processed foods.
- Develop sustainable, patient-centered nutrition plans integrated with other cardiovascular therapies.
Deanna Minich, PhD
5:00 pm
Panel Discussion: Translating Cardiometabolic Science into Longevity Practice
- Translate emerging cardiometabolic evidence into actionable longevity protocols.
- Integrate pharmacology, exercise, and nutrition strategies in real-world cases.
Faculty
5:30 pm
Close of Session
DECEMBER 13, 2026
Women's Cardiovascular Health | CHD, Heart Failure & Arrhythmia | Biomarkers & Regenerative Medicine
Cluster 5 -- Women's Cardiovascular Health
8:00 am
Women's Cardiovascular Health: Risk, Presentation, and Prevention
- Identify sex-specific cardiovascular risk factors, including microvascular and autoimmune drivers.
- Evaluate atypical presentations of coronary disease, MI, and heart failure in women.
- Design integrative, sex-specific cardiovascular care plans across the lifespan.
Mimi Guarneri, MD
9:00 am
Perimenopause, HRT, and Cardiometabolic Risk
- Describe how perimenopause and menopause accelerate cardiometabolic risk.
- Review the evidence on HRT, the timing hypothesis, and cardiovascular outcomes.
- Integrate HRT and non-hormonal strategies into longevity-focused care for women.
Felice Gersh, MD
10:00 am
Break
Cluster 6 -- Coronary Heart Disease, Heart Failure, Arrhythmia & CKM Syndrome
10:30 am
Coronary Heart Disease and Heart Failure: Precision Prevention and Treatment
- Explain CHD, MI, and heart failure through a systems-based, integrative lens.
- Evaluate advanced risk factors, including lipoprotein genetics, inflammation, and metabolic drivers.
- Integrate cardiovascular nutrition, nutrigenomics, and precision supplementation into prevention.
Mark Houston, MD, MS, MSc
11:30 am
HFpEF, Atrial Fibrillation, and CKM Syndrome
- Describe the inflammatory, metabolic, and microvascular drivers of HFpEF.
- Identify modifiable factors in atrial fibrillation, including autonomic, sleep, and metabolic drivers.
- Apply the CKM Syndrome framework to manage overlapping cardiometabolic and renal risk.
Sanjay Bhojraj, MD
12:30 pm
Lunch & Car Giveaway in Exhibit Hall
1:30 pm
CHD and Heart Failure in Practice: Cases and Treatment Planning
- Develop personalized secondary prevention plans for post-MI and CHD patients.
- Evaluate integrative heart failure strategies, including targeted supplementation and lifestyle interventions.
- Apply pharmacogenomics and advanced biomarkers to optimize long-term cardiovascular care.
Mark Houston, MD, MS, MSc
Cluster 7 -- Biomarkers, Regenerative Medicine & Brain-Heart Connection
2:30 pm
Biomarkers and Multi-Omics in Longevity Cardiology
- Differentiate traditional cardiovascular biomarkers from multi-omics and epigenetic assessments.
- Describe the role of proteomics and metabolomics in early detection and treatment monitoring.
- Interpret integrated biomarker panels to guide individualized longevity cardiology care.
George Shapiro, MD
3:30 pm
Break
4:00 pm
Regenerative Strategies in Cardiovascular Longevity
- Distinguish conventional cardiometabolic care from regenerative longevity frameworks.
- Sequence lifestyle, pharmacologic, nutraceutical, and regenerative therapies across the patient journey.
- Construct personalized cardiovascular longevity roadmaps using complex case examples.
George Shapiro, MD
5:00 pm
The Future of Cardiovascular Longevity Medicine
- Identify emerging directions shaping the next decade of cardiovascular longevity medicine.
- Integrate evolving science into clinical practice and long-term patient programs.
George Shapiro, MD
5:30 pm
Close of Session
Venue
The Venetian And Palazzo Resort
3355 S. Las Vegas Blvd. Las Vegas, NV 89109
Room Rate: $309 - $359
Expires: 11-13-26
Venetian | Group Code: RUSHD
Toll-free: (866) 659-9645
International: (702) 414-1100
Palazzo - (866) 659-9659
Booking Link: https://book.passkey.com/go/A4M26
Cancellation Policy
A one night's deposit is due at the time of booking. The cancellation policy for your reservation is 30 DAYS prior to arrival. If the reservation is canceled within 30 days of arrival, your one-night deposit will be forfeited.