Fellowship in longevity medicine

Module II

Neurovascular and Metabolic Synergy

The Venetian & Palazzo · Las Vegas, Nevada

Earn up to 20.5 CME credits

Allied Health $2,250 · Physician $2,750 · 3 days

Unlock the power of interconnected systems to transform patient care.

Module II of A4M’s Fellowship in Longevity Medicine explores the complex synergy between the gut, brain, metabolic, and cardiovascular systems—offering a comprehensive framework for diagnosing, preventing, and treating chronic conditions at their root.

Key focus areas

What you'll learn

Cardiovascular Health

Foundations of Heart Health: Identify the roles of diet, physical activity, and stress regulation in cardiovascular outcomes.

Risk Reduction: Learn to spot early warning signs and apply preventive strategies.

Integrative Approaches: Incorporate lifestyle and functional medicine into heart care.

Blood Sugar & Metabolic Health

Glucose & Insulin Dynamics: Understand the mechanisms of glucose metabolism and insulin sensitivity.

Lifestyle & Metabolism: Investigate how nutrition, exercise, and stress impact metabolic function.

Managing Metabolic Syndrome: Prevent and treat insulin resistance, Type 2 diabetes, and related conditions.

Gut Health & Immunity

The Microbiome & Wellness: Examine how gut microbes influence immune response, inflammation, and chronic disease risk.

The Gut-Brain Axis: Explore the two-way communication between the GI tract and the brain—linking digestion to mood, memory, and cognition.

Gastrointestinal Disorders: Learn diagnostic strategies and therapeutic interventions for common GI issues.

Brain Health & Cognition

Neurobiology of Function: Delve into the cellular and molecular foundations of cognition and emotional health.

Metabolism & the Mind: Discover the impact of blood sugar and nutrient delivery on brain function.

Cognitive Longevity: Gain tools for early detection, risk reduction, and enhancement of mental performance.

What You'll Gain from This Module

  • Assess and manage cardiovascular risk using holistic protocols
  • Design comprehensive, multi-system care strategies for longevity-focused practice
  • Understand the principles of blood sugar regulation and its impact on chronic disease

Fellowship

About the Fellowship in Longevity Medicine

The A4M Fellowship in Longevity Medicine is the world’s premier training program for healthcare professionals committed to extending healthspan, preventing disease, and transforming the future of aging.

Grounded in the latest clinical research and real-world application, the Fellowship provides the knowledge, tools, and credentials to practice cutting-edge, personalized medicine.

Learn more

Learn from clinicians in the trenches.

Sanjay Bhojraj

MD

Sanjay Bhojraj

MD

Sanjay Bhojraj, MD, FACC is an interventional cardiologist and Fellow of the American Academy of Anti-Aging Medicine (A4M) specializing in cardiometabolic health, longevity medicine, and precision cardiovascular prevention. With more than two decades of experience in advanced cardiovascular care, he combines conventional cardiology with root-cause and lifestyle medicine to help patients address the metabolic drivers of heart disease.

Dr. Bhojraj is the founder of the Laguna Institute of Functional Medicine, where he leads group-based cardiometabolic optimization programs and a concierge integrative cardiology and longevity practice. His programs focus on reversing metabolic dysfunction, improving energy and resilience, and reducing cardiovascular risk through targeted nutrition, sleep optimization, stress regulation, strength training, and advanced diagnostic testing.

He also works with patients using GLP-1 medications to develop safe metabolic transition strategies that support sustainable weight management while preserving metabolic health.

Through his clinical work, teaching, and digital health programs, Dr. Bhojraj is helping shape a new model of cardiovascular care—one that moves beyond reactive treatment toward proactive metabolic optimization and long-term healthspan.

Full profile

Christopher Davis

MD, FACC

Christopher Davis

MD, FACC

Dr. Christopher Davis is a triple board-certified integrative interventional cardiologist with a passion for educating and empowering individuals to take control of their own health. He is the founder of Reveal Vitality and Longevity Institute, Chief Medical Officer of Liquivida, and Chief Cardiologist at humann. Dr. Davis completed his undergraduate education at Duke University and medical school at Eastern Virginia Medical School. He completed his internal medicine residency at Johns Hopkins University-Sinai Hospital and went on to serve as chief medical resident at Johns Hopkins. He then completed a four-year general cardiology fellowship as an NIH fellow and an additional one-year interventional cardiology fellowship at the University of Virginia. After 10 years of traditional medical practice, Dr. Davis realized that there were some major shortfalls of our current healthcare system. In 2017 he set out to provide the type of medical care his patients desired and deserved. He founded Reveal Vitality to deliver a personalized, precision and comprehensive health assessment for each of his clients. The expansion of this vision has recently culminated in REVEAL, a world class fitness, vitality and longevity center in Sarasota, Florida. Here he incorporates advanced therapeutics such as IV nutrient therapy, hyperbaric oxygen therapy, photobiomodulation, cryotherapy, and many other novel modalities to enable all of his clients to achieve their ultimate human potential.

Felice Gersh

MD

Felice Gersh

MD

Felice Gersh, M.D. is a multi-award winning physician with dual board certifications in OB-GYN and Integrative Medicine. She is the founder and director of the Integrative Medical Group of Irvine, a practice that provides comprehensive health care for women by combining the best evidence-based therapies from conventional, naturopathic, and holistic medicine. She received her education at Princeton University, USC School of Medicine, Kaiser Hospital, and University of Arizona School of Medicine. She received the highly coveted Outstanding Volunteer Clinical Faculty Award, while teaching obstetrics and gynecology at Keck USC School of Medicine, where she served for 12 years as an Assistant Clinical Professor. She now serves as an Affiliate Faculty Member at the Fellowship in Integrative Medicine, through the University of Arizona School of Medicine, where she mentors and regularly grades the case presentations written by the Fellowship students for their final exams.

Felice Gersh, M.D. is the bestselling author of PCOS SOS, PCOS SOS Fertility Fast Track, and Menopause: 50 Things You Need to Know. She has also had numerous scientific articles published in peer-reviewed medical journals. Dr. Gersh is a prolific lecturer and has been featured in several films and documentary series, including The Real Skinny on Fat with Montel Williams, Fasting with Valter Longo, Ph.D., and The Business of Birth Control.

Full profile

Mimi Guarneri

MD

Mimi Guarneri

MD

Board-certified in Cardiovascular Disease, Internal Medicine and Integrative Holistic Medicine, Mimi Guarneri, MD, FACC, ABOIM is a cardiologist focusing on disease prevention and health a creation. A leading proponent of Integrative Medicine, she served on the Founding Board of the American Board Physician Specialties in Integrative Medicine (ABOIM). She is Co-founder and Medical Director of Guarneri Integrative Health, Inc. at Pacific Pearl La Jolla in La Jolla, California, USA, where she leads a team of experts in conventional, integrative, and natural medicine. Dr. Guarneri is Co-founder and Treasurer of Miraglo Foundation, a non-profit public charity providing Integrative Medicine education and research; and serving the underserved in the U.S. and globally. A Clinical Associate Professor at University of California, San Diego (UCSD), California North State University and Southern California University Health Sciences.

She also is President of the Academy of Integrative Health and Medicine (AIHM) and the Past President of the American Board of Integrative Holistic Medicine (ABIHM). She served as Senior Advisor to the Atlantic Health System for the Chambers Center for Well Being, among other healthcare system advisory positions. She is an accomplished author and the Professor of The Great Courses video series, “The Science of Natural Healing.” Her television special, “Live Better Now with Mimi Guarneri, MD,” in 2019 and 2020 was broadcasted at hundreds of public television stations across the U.S. Dr. Guarneri hosted “The Heart Health” series for Food Revolution Network in 2021.

Full profile

Joel Jamieson

Joel Jamieson

Joel Jamieson is a conditioning coach, author, and educator who has spent more than 25 years training elite athletes, MMA world champions, Olympians, NFL players, and special operations personnel.

He built his reputation in mixed martial arts and is widely regarded as one of the world's leading authorities on conditioning and energy systems. Joel is the author of Ultimate MMA Conditioning, the founder of 8WeeksOut and the creator of Morpheus, a personalized cardio system that brings his approach building lasting cardiovascular fitness to everyone.

Full profile

Joel Kahn

MD, FACC

Joel Kahn

MD, FACC

Joel Kahn, MD, FACC of Detroit, Michigan, is a practicing cardiologist, and a Clinical Professor of Medicine at Wayne State University School of Medicine. He graduated Summa Cum Laude from the University of Michigan Medical School. Known as “America’s Healthy Heart Doc”, Dr. Kahn has triple board certification in Internal Medicine, Cardiovascular Medicine and Interventional Cardiology. He was the first physician in the world to certify in Metabolic Cardiology with A4M/MMI and the University of South Florida. He founded the Kahn Center for Cardiac Longevity in Bingham Farms, MI.

Dr. Kahn has authored scores of publications in his field including articles, book chapters and monographs. He writes health articles and has 6 books in publication including Your Whole Heart Solution, Dead Execs Don’t Get Bonuses and The Plant Based Solution, and Lipoprotein(a): The Heart’s Silent Killer. He has regular appearances on Dr. Phil, The Doctors Show, Dr. Oz, Larry King Now, Joe Rogan Experience, and with Bassem Yousef. He has been awarded a Health Hero award from Detroit Crain’s Business. Dr. Kahn also leads the annual online summit Reversing Heart Disease Naturally.

Dr. Kahn can be found at www.drjoelkahn.com.

Full profile

Kiran Krishnan

PhD

Kiran Krishnan

PhD

Kiran is a research microbiologist and a health and wellness expert who aims to make complex information understandable to all. He has founded a number of successful health and supplement companies over the last 15 years including co-founding and leading Microbiome Labs, the preeminent, microbiome therapeutics-focused brand among healthcare professionals. He is currently a co-founder and partner in 3 other companies that aim to revolutionize wellness care. He has conducted and published several research studies in scientific journals, has published chapters in scientific textbooks/references books, has global patents and is a sought after speaker on human health and the microbiome.

Full profile

Todd LePine

MD

Todd LePine

MD

Dr. Todd LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. Additionally, he has advanced clinical training and is certified through the Institute for Functional Medicine. Dr. LePine is a staff physician with Dr. Mark Hyman at The UltraWellness Center located in Lenox, Massachusetts in the Berkshires. Prior to joining the UltraWellness Center Dr. LePine worked as a staff physician at Canyon Ranch Health Spa in Lenox, Massachusetts consulting with patients from around the world looking for optimal health. He is a faculty member of the American Academy of Anti-Aging Medicine. His areas of interest within medicine include: The Human Microbiome and its effect in health and disease, the neurobiology of mood and cognitive disorders. NutriGenomics, Optimal Aging, Autoimmune diseases and Detoxification.

Full profile

Deanna Minich

PhD

Deanna Minich

PhD

Deanna Minich, PhD, MS, CNS, FMCP, is a nutrition scientist, researcher, international lecturer, educator, and author with over 25 years of cumulative experience in academia and the food and dietary supplement industries. Throughout the years, she has been active as a functional medicine clinician in clinical trials and her practice (Food & Spirit™), which has become oriented toward groups, workshops, and retreats. She is the author of seven consumer books on wellness topics (e.g., The Rainbow Diet), four book chapters, and over 50 scientific publications. Her academic background is in nutrition science, including a Master of Science in Nutrition and Dietetics and a Doctorate in Medical Science (PhD). For a decade, she was part of the research team led by the “Father of Functional Medicine,” Dr. Jeffrey Bland, and has served on the Nutrition Advisory Board for The Institute for Functional Medicine and the Board of Directors for the American Nutrition Association. Since 2013, she has been part of the faculty for the Advanced Practice Module in Environmental Health offered by The Institute for Functional Medicine. She has been teaching a graduate-level course in metabolic detoxification at the University of Western States. Over the decades, she has trained thousands of health and nutrition-related classes for health coaches, fitness trainers, and healthcare professionals, including for programs offered by the Functional Medicine Coaching Academy, the Integrative and Functional Nutrition Academy, the Institute for Brain Potential, and the Institute for Integrative Nutrition. She is a Fellow of the American College of Nutrition (FACN) and a Certified Nutrition Specialist (CNS). She serves as Chief Science Officer at Symphony Natural Health, where she leads the Medical Team, oversees scientific communication, and provides educational leadership for the company’s plant-derived nutraceuticals. In 2025, she received the Linus and Ava Helen Pauling Award in Functional Medicine. She is passionate about helping others to live well using therapeutic lifestyle changes that impact their physical, emotional, mental, and spiritual health. Visit her at: www.deannaminich.com

Full profile

George Shapiro

MD

George Shapiro

MD

Dr. George C. Shapiro, MD, FACC is Chief Medical Officer of ZeoScientifiX and a board-certified physician in Internal Medicine and Cardiovascular Disease.

He is also a co-founder and former Chief Medical Innovation Officer of Fountain Life, where he helped develop a precision longevity platform integrating advanced diagnostics and biologic therapies.

Dr. Shapiro is a former Assistant Professor of Clinical Medicine at Columbia University College of Physicians and Surgeons and has held additional academic appointments at NYU School of Medicine and New York Medical College.

With more than 35 years of clinical experience, his work focuses on regenerative biologics, extracellular vesicle therapeutics, and biomarker-driven approaches to improving human healthspan.

He completed his fellowship in Cardiovascular Disease at Columbia University College of Physicians and Surgeons and his internship and residency in Internal Medicine at Albert Einstein College of Medicine, with clinical training at Jacobi Medical Center and Montefiore Medical Center. He has also served as an Attending Physician at NewYork-Presbyterian Hospital.

Dr. Shapiro has served as Principal Investigator or investigator on multiple FDA-regulated clinical studies, including IND-authorized Phase I/II trials evaluating extracellular vesicle biologics across indications such as COVID-19 respiratory disease, chronic obstructive pulmonary disease, osteoarthritis, traumatic brain injury, and post-viral inflammatory syndromes. His work focuses on translating emerging biologic science into clinically deployable therapies targeting the underlying mechanisms of aging.

He is a recognized leader in age management and regenerative medicine and previously served as President and Medical Director of Cenegenics New York City, where he led one of the nation’s premier age-management practices. He is the recipient of the Alan P. Mintz, MD Award for Clinical Excellence in Age Management Medicine and is a frequent faculty speaker for A4M and AMMG.

Dr. Shapiro is also a contributor to Life Force (Tony Robbins and Peter Diamandis) and served as Executive Producer of the documentaries Longevity Hackers and Longevity Revolution. His current work focuses on advancing next-generation biologic platforms designed to modulate cellular signaling, restore tissue function, and target the biology of aging.

Full profile

Schedule

The agenda.

Three days in Las Vegas, December 11–13, 2026. Choose a day to see each session, its faculty and learning objectives.

Day 1 · Friday, December 11, 2026

  1. 7:00-8:00 am

    Breakfast Sponsored by Calroy (Non-CME)

    Beyond Estrogen: The New Blueprint for Women’s Longevity

    Dr. Christine Maren, D.O., ABFM, IFMCP, MSCP & Kiran Krishnan, PhD

    Register Now

    Open to the first 150 registrants

  2. Cluster 1: Vascular Biology, Modern Exposures & Gut-Heart-Metabolic Axis
  3. 8:00–9:00 am

    Vascular Biology in the Modern World

    Christopher Davis, MD, FACC

    Show learning objectives (3)
    • Explain endothelial function, arterial stiffness, inflammation, and vascular aging.
    • Evaluate evidence for air pollution and metals and emerging data on microplastics.
    • Identify proven endothelial protection: BP and ApoB control, smoking cessation, exercise, and diet.
  4. 9:00–10:30 am

    The Gut-Heart-Metabolic Axis

    Todd LePine, MD

    Show learning objectives (3)
    • Explain how insulin resistance, diet, gut signals, and inflammation affect vascular function.
    • Distinguish mechanisms from interventions with cardiovascular outcome data.
    • Apply evidence-based lifestyle and metabolic risk reduction to clinical cases.
  5. 10:30–11:00 am

    Break

  6. 11:00 am–12:00 pm

    Why Hypertension Develops: Mechanisms and Evaluation

    Sanjay Bhojraj, MD

    Show learning objectives (3)
    • Connect vascular, renal, autonomic, sleep, and metabolic mechanisms to blood pressure elevation.
    • Use office and home BP monitoring to establish the phenotype.
    • Select targeted evaluation for secondary causes.
  7. 12:00–1:00 pm

    Lunch Sponsored by KBMO (Non-CME)

    What Are We Missing? Immune Reactivity and Mycotoxin Diagnostics as a Window Into the Terrain

    Nasha Winters, ND, FABNO

  8. Cluster 2: Hypertension: Guideline, Management & Case Applications
  9. 1:30–3:00 pm

    Hypertension in Practice: Advanced Management

    Sanjay Bhojraj, MD

    Show learning objectives (4)
    • Apply the 2025 AHA/ACC Hypertension Guideline in Longevity Practice for diagnosis, risk assessment, and treatment decisions.
    • Evaluate resistant, masked, white-coat, and secondary hypertension.
    • Select drugs and lifestyle care for individual risk and comorbidity.
    • Design monitoring and escalation plans for complex patients.
  10. 3:00–3:30 pm

    Break

  11. 3:30–4:00 pm

    Healthspan: Why Cartilage, Microvasculature, and Inflammation Matter

    Kiran Krishnan, PhD

    Show learning objectives (3)
    • Critically analyze the bidirectional relationship between cartilage degeneration, systemic inflammatory pathways, and cardiometabolic risk factors.
    • Introduce a multipronged approach to support joint health and cartilage regeneration.
    • Review data from 3 human clinical trials demonstrating improvements in key cartilage regeneration biomarkers, pain scores, and functional walk distance.
  12. 4:00–5:00 pm

    Hypertension Panel: Applying Longevity Principles to Complex Case Decisions

    Joel Kahn, MD, FACC; Sanjay Bhojraj, MD; Todd LePine, MD

    Show learning objectives (2)
    • Integrate mechanisms, guideline therapy, and systems biology approach to hypertension.
    • Identify when additional testing or referral changes in management.
  13. 5:00–6:00 pm

    Biomarkers and Multi-Omics in Longevity Cardiology

    George Shapiro, MD

    Show learning objectives (3)
    • Differentiate traditional cardiovascular biomarkers from multi-omics and epigenetic assessments.
    • Describe the role of proteomics and metabolomics in early detection and treatment monitoring.
    • Interpret integrated biomarker panels to guide individualized longevity cardiology care.
  14. 6:00 pm

    Close of Session

Times and faculty subject to change.

Ready to transform patient outcomes?

Join us this December in Las Vegas for Module II: Neurovascular and Metabolic Synergy.

A 3-day program on the synergy between the gut, brain, metabolic, and cardiovascular systems — built for clinicians ready to diagnose, prevent, and treat chronic conditions at their root.

Registration

Allied health

$2,250 USD

Register

Physician

$2,750 USD

Register

Per attendee · 3 days

Venue

Venue information.

Every session takes place at the center of the Las Vegas Strip.

The Venetian Resort at night
Pool deck
Gondola on the Grand Canal at the Venetian
Grand Canal Shoppes

Event venue & host hotel

The Venetian & Palazzo Resort

3355 S. Las Vegas Blvd. · Las Vegas, NV 89109


Call center
866.659.9643Toll-free
International
702.414.4100Local number
CutOff Date
November 13, 2026

Limited availability. Room rates vary.

Book your room

Stay

Hotel information.

Rooms at the host hotel are limited. Our group room blocks are also available at Treasure Island Las Vegas and Wynn and Encore Las Vegas.

Group hotel

Treasure Island Las Vegas

3300 Las Vegas Blvd S · Las Vegas, NV 89109


Group name
A4M Longevity Fest
Group code
A4MLF
Cutoff date
Nov 16, 2026Book early to secure
Reservations
800-944-7444or 702-894-7444

*Room rates vary and are subject to availability.

Book your room

Group hotel

Wynn and Encore Las Vegas

3131 Las Vegas Blvd. S. · Las Vegas, NV 89109


Cutoff date
Nov 18, 2026
Reservations
866-770-7555or 702-770-2222

Book your room