Regenerative & Reparative Peptides
Regenerative & Reparative Peptides
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BPC-157: Promotes healing, angiogenesis, and reduces inflammation; used for GI repair, tissue regeneration, and nervous system recovery.
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Thymosin Beta-4 (TB4): Supports cell migration, wound healing, neuroregeneration, and tissue remodeling.
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KPV (Lysine-Proline-Valine): Tripeptide with anti-inflammatory effects; supports gut integrity, wound healing, and mast cell stabilization.
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RGN-259: A TB4-derived peptide under study for treating neurotrophic keratitis.
Neuroprotective & Cognitive Peptides
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VIP (Vasoactive Intestinal Peptide): Modulates neuroimmune function, reduces inflammation, and supports circadian rhythm; used in Chronic Inflammatory Response Syndrome (CIRS).
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Selank: Anxiolytic and nootropic; enhances cognition and mood.
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PE-22-28: A spadin analog with antidepressant and neurogenic effects.
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PT-141 (Bremelanotide): A melanocortin receptor agonist with mood and sexual function benefits.
Growth Hormone Axis & Metabolism
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CJC-1295/Ipamorelin: Stimulate growth hormone release; used for sleep, recovery, muscle growth, and cognition.
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Sermorelin: GHRH analog for promoting natural GH/IGF-1 production; anti-aging and body composition.
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Tesamorelin: GHRH analog used to reduce visceral fat and support cognitive performance and liver health in lipodystrophy and NAFLD.
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GHRH / ALRN-5281: Peptides targeting GH axis; related to insulin sensitivity, thymic support, and oxidative stress control.
Appetite, Anabolic & Energy Regulation
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Ghrelin / Macimorelin: Appetite-stimulating peptides; Macimorelin is a ghrelin receptor agonist used for GH testing and potential in cachexia.
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MOTS-c: Mitochondrial-derived peptide; boosts insulin sensitivity and supports metabolic health.
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Nicotinamide Riboside (NR): NAD+ precursor enhancing mitochondrial function and cognitive resilience (not a peptide per se, but often used in peptide protocols).
Gut & Barrier Function Peptides
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Larazotide (AT-1001): Regulates tight junctions for intestinal permeability and is used in leaky gut, celiac disease, and autoimmune conditions.
Metabolic & Cardiovascular Peptides
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GLP-1 Agonists (Multiple peptides: Semaglutide, Tirzepatide, Liraglutide, Dulaglutide, Exenatide, Lixisenatide): Regulate blood sugar, reduce weight, and exhibit neuroprotective effects. Tirzepatide acts on dual GLP-1/GIP pathways.
Immune Modulation Peptides
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Thymosin Alpha-1 (TA1): Boosts immune function; effective in viral infections, immune aging, and chronic inflammation.
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Low Dose Naltrexone (LDN): Though not a peptide, it is frequently co-administered in peptide protocols for managing autoimmunity and chronic inflammation.
Inflammation-Modulating & Adjunctive Compounds
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IRW Peptide: Ovotransferrin-derived; anti-inflammatory, supports PGC1α and mitochondrial metabolism.
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TUDCA: Bile acid derivative often used with peptides in neurodegenerative and metabolic protocols.
Amino-Acid-based & Signaling Compounds
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SPMs (Specialized Pro-Resolving Mediators): While technically not peptides, included for their overlapping use in inflammation resolution.
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Wheat-Bran Peptides (LRP & LQP): Leucine-rich; studied for NASH and oxidative stress, AMPK activation, and mitochondrial function.
Quick View: Clinical Use Categories
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Clinical Focus |
Key Peptides |
| Tissue Repair |
BPC-157, TB4, KPV, RGN-259 |
| Neurocognitive Health |
VIP, Selank, PE-22-28, PT-141, NR |
| GH Axis & Recovery |
CJC/Ipamorelin, Sermorelin, Tesamorelin |
| Energy & Metabolism |
MOTS-c, Ghrelin, Macimorelin |
| Gut/Barrier Function |
Larazotide, KPV |
| Metabolic Regulation |
GLP-1 Agonists (e.g., Tirzepatide) |
| Immune Modulation |
TA1, LDN, KPV, VIP |
| Mitochondrial Support |
NR, IRW, LRP/LQP, TUDCA |