In this episode, recorded live at LongevityFest 2025, Dr. Jeff Gladd and Ben Walters discuss Fullscript's transition into an AI-driven "whole person care" operating system designed to solve practitioner burnout and scale clinical outcomes. The conversation explores the impact of Fullscript Assist, an AI treatment layer that generates evidence-based plans and automates safety checks for medication-induced nutrient depletions. A major highlight is "Journeys," a clinical workflow tool that aggregates fragmented data from intake forms, lab results, and wearable devices into a single real-time dashboard. By "codifying the algorithm" of a practitioner's clinical style, this technology can reduce the time required for lab interpretation and wellness plan creation from nearly an hour to under seven minutes, allowing clinicians to manage up to five times more patients while maintaining high-quality care. By shifting from subjective testimonials to objective data through the PROMIS-10 framework, Fullscript is effectively moving the clinical experience from a manual "paper map" to a high-precision GPS system for patient health.

In this episode of the Innovations and Clinical Implementation podcast, hosts Dr. Lexi Gonzales and Tom Blue interview Dr. Sundeep Dugar, a pharmaceutical drug hunter with nearly 40 years of experience in small molecule discovery who serves as the co-founder and Chief Scientific Officer at Blue Oak Nutraceuticals. The conversation focuses on the development of Mitocatalyst, a precision-formulated epicatechin designed to mimic the mitochondrial biogenesis normally triggered by exercise. Dr. Dugar reveals his breakthrough discovery that exercise-induced Reactive Oxygen Species (ROS) signal the mitochondria to produce a specific steroid—11-beta hydroxyprogesterone—and explains how Mitocatalyst utilizes nanomolar doses of epicatechin to molecularly mimic this steroid, distinguishing it from high-dose antioxidant protocols that paradoxically blunt these beneficial signals. The discussion uses the metaphor of building a "fireplace" (mitochondria) to burn "firewood" (nutrition), positioning the supplement as a critical intervention for aging patients or those unable to exercise.

In this episode of the Innovations and Clinical Implementation podcast, hosts Tom Blue and Sonia Horner discuss the future of AI-driven medicine with Dr. Don Brown, a physician entrepreneur and the former founder of LifeOmic who emerged from retirement to create Bioscope.ai. The conversation explores how Bioscope.ai functions as a revolutionary "AI Medical Colleague" by aggregating vast datasets—including whole genome sequencing, EMRs, and multi-omics—into a secure cloud repository that feeds an orchestration layer of multiple LLMs grounded in academic research. Dr. Brown details the platform's "synoptic view," an interface inspired by high-performance aircraft that visualizes 15 dimensions of health on a 3D wireframe, and introduces "Lumina," an AI persona that learns a physician's specific style to generate personalized care plans, ultimately allowing practices to offer high-value subscription models that turn static health data into a dynamic asset.

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores the intersection of AI and gut health with Dr. Helen Messier, a physician and molecular immunologist who serves as the Chief Medical and Science Officer at Fountain Life; Dr. Leo Grady, the founder of Jona and an AI expert who previously led the team achieving the first FDA approval for an AI product in pathology; and Dr. Lawrence Kosinski, a gastroenterologist and founder of Sonar MD who is a national leader in value-based care. The panel discusses how Jona’s AI platform processes over 220,000 studies to identify dysbiotic patterns that antedate clinical disease—ranging from metabolic liver disease and colon polyps to Parkinson’s and cardiovascular issues linked to TMAO—thereby moving clinical focus from "symptoms to systems". The experts emphasize the mechanism of the gut-brain axis, noting that metabolites like butyrate derived from soluble fiber are essential for stabilizing the blood-brain barrier and DNA, while warning that popular GLP-1 agonists, though effective for weight loss, can "collapse" microbiome diversity and require careful monitoring.

In this episode of the *Innovations and Clinical Implementation* podcast recorded at LongevityFest, hosts Tom Blue and Chris D'Adamo discuss the rapid evolution of epigenetic testing with Ryan Smith. Ryan Smith is the founder and global head of research and development at TruDiagnostic, a CLIA-certified lab and health data company that has built one of the world's largest private epigenetic databases to advance the measurement of biological aging. The discussion traces the 140% year-over-year growth in consumer interest regarding biological age and explores how TruDiagnostic utilizes AI to interpret over 1.3 million DNA methylation sites to validate longevity interventions in clinical trials. Smith previews the upcoming release of "methylation risk scores" that can predict the onset of diseases like COPD and Lyme disease, and details the development of "Epigenetic Biomarker Proxies" (EBPs) intended to eventually replace traditional labs by deriving thousands of metrics—such as HbA1c, CRP, and environmental toxins—from a single finger stick.

In this episode of the Innovations and Clinical Implementation podcast, hosts Andy Crosby and Dr. Chris D’Adamo explore the synergistic role of nitric oxide and hydrogen sulfide in male sexual longevity with Dr. Miles Spar—a leading authority and educator specializing in men's health and personalized performance medicine. The discussion centers on a recent 600-person randomized trial of Calroy Health Sciences’ Vasconox HP, which demonstrated that hydrogen sulfide acts as a natural PDE5 inhibitor to extend the vasodilating effects of nitric oxide for up to 24 hours, significantly improving erectile function and orgasm ability compared to placebo. Dr. Spar highlights the clinical importance of addressing upstream endothelial health rather than relying solely on pharmaceuticals, noting that treating erectile dysfunction in patients with poor metabolic health without fixing nitric oxide production is akin to "filling a bathtub with the drain open".

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest, host Tom Blue interviews Harry Bane, CEO of Lifespan.MD, about a novel investment model for concierge medicine dubbed "Entrepreneurial Equity". Unlike traditional private equity that often focuses on cost-cutting, Bane explains that Lifespan.MD builds long-term partnerships with established physician-entrepreneurs, allowing them to retain clinical autonomy while leveraging shared infrastructure, AI technology, and a collaborative "brain trust" to drive organic growth rates of 30–40%. The conversation highlights the company's origin story—born from a patient-doctor relationship—and its five core values, emphasizing how the model reinvigorates practitioners by turning their practices into tangible wealth assets through equity while solving critical succession planning and supply-demand challenges in the longevity sector.

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, hosts Jessica Carter and Dr. Lexi Gonzales explore advanced cellular rejuvenation strategies with Dr. Greg Kelly—a naturopathic physician, author of Shape Shift, and Senior Director of Product Development at Qualia who is a leading expert in nootropics and longevity science. Dr. Kelly outlines a "gardening" approach to cellular health, advocating for an intermittent "hit-and-run" dosing protocol where senolytics are used to "prune" inflammatory senescent cells (the "yellow leaves") before introducing stem cell support, rather than using daily dosing which can lead to adaptation or exhaustion. He utilizes the analogy of the "four doors" of cellular stress to explain why clearing the biological terrain of "zombie cells" is a necessary prerequisite for effective stem cell therapy, ultimately recommending a practical monthly cycle—such as two days of senolytics followed by four days of stem cell support—to reduce systemic inflammation and improve cognitive function.

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, hosts Dr. Lexi Gonzales and Tom Blue explore the frontier of liposomal peptide therapy with Dr. Christopher Shade—the founder and CEO of Quicksilver Scientific and an internationally recognized expert on environmental toxicants who pioneered the use of lipid-based nanoparticle delivery systems. Dr. Shade argues that "inflammaging" and endotoxemia often block the efficacy of standard hormone therapies by downregulating receptors, and he advocates for using specific liposomal peptides like BPC-157, KPV, and Thymulin to break these inflammatory cycles and reverse "fatty thymus." The conversation details how intraoral nanoliposomes utilize membrane fusion to achieve high intracellular uptake, offering practitioners a compliant, scalable method to transition from symptom-chasing "personalized medicine" to upstream "precision medicine" that rapidly seals the gut and resets immune resilience.

In this episode of the Innovations and Clinical Implementation podcast, hosts Jessica Carter and Dr. Chris D’Adamo interview Dr. Jill Carnahan, a functional medicine physician internationally recognized for treating complex chronic illnesses, about the critical role of beta glucans in immune resilience—which she champions as the foundation of longevity. Dr. Carnahan discusses the importance of using high-purity beta glucans, profiling BWH Labs’ flagship product, and details their use in treating complex conditions like Lyme disease, Bartonella, and cancer where the immune system is often suppressed. The conversation also covers emerging research linking beta-glucan supplementation to improved mental health scores (anxiety and depression) and its mechanism as a binder in detoxification pathways for removing environmental toxins. Finally, Dr. Carnahan underscores that while lifestyle factors like sleep and movement are foundational, beta-glucans serve as a crucial tool for “waking up” sluggish T-cells and Natural Killer cells to fight aging and chronic illness.

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, hosts Dr. Lexi Gonzales and Jessica Carter discuss functional liver health with Dr. Karan Krishnan—a research microbiologist and globally recognized expert on the human microbiome and co-founded Microbiome Labs. Dr. Krishnan argues that standard enzymes like AST and ALT are late-stage markers of damage, and instead advocates for proactive support using Dose, a clinically validated liquid therapeutic that serves as a foundational tool for metabolic health and reduces pill burden. The conversation explores the vicious cycle between liver dysfunction and dysbiosis—where "leaky gut" increases endotoxin load (measurable via LBP and HDL3) and reduced bile flow drives SIBO—and explains that Dose is uniquely formulated without black pepper to ensure curcuminoids are metabolized locally by the liver for repair rather than being shunted into systemic circulation.

In this episode of the Innovations and Clinical Implementation podcast, hosts Dr. Lexi Gonzales and Dr. Chris D’Adamo explore the critical role of biofilm management in gut health and longevity with Dr. Jocelyn Strand. Dr. Strand is a Naturopathic Doctor and the Director of Clinical Education and Research at Biocidin Botanicals, bringing over a decade of primary care experience specializing in GI disorders, Lyme disease, and autoimmune conditions. The discussion defines biofilms as an “invisibility cloak” that protects microorganisms from the immune system, leading to chronic inflammation and toxicity when pathogenic bacteria translocate from the mouth to the gut. Dr. Strand outlines a clinical approach that focuses on restoring balance rather than “wiping out” the microbiome, recommending a “low and slow” titration of Biocidin liquid to disrupt biofilms within a standard 5R protocol without causing significant die-off reactions. Finally, the group previews a new study examining Biocidin’s ability to reduce oral biofilms in healthy subjects, underscoring the vital link between oral hygiene and systemic health.

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores how AI is revolutionizing functional medicine workflows with guests Sunita Mohanty and Crystal Brust. Sunita Mohanty is the CEO and co-founder of Ultralight (formerly Vibrant Practice) and Crystal Brust is a Stanford-trained functional medicine Physician Assistant and founder of Farm to Functional Medicine. The conversation highlights how the Vibrant Practice platform addresses clinician burnout by integrating AI directly into the electronic health record (EHR) to automate documentation and synthesize complex patient data—such as genetics and timelines—into actionable insights. The guests emphasize that this "full stack" approach not only saves time but transforms the medical record from a static repository into an interactive tool that restores joy, creativity, and confidence to the provider-patient relationship.

In this episode of the Innovations and Clinical Implementation podcast, Dr. Lexi Gonzales and Dr. Sunjya Schweig discuss the shift for clinicians from passively consuming AI to actively building custom tools to improve patient outcomes and reduce clinical friction. Key topics include the use of custom GPTs created by uploading specific data, the potential of "vibe coding" for building apps with natural language, and the evolution of AI scribes like Heidi as a "second brain." The conversation also addresses challenges in integrating AI with legacy EMRs, the push for "health record equity," and actionable advice for practitioners to start experimenting with AI tools like NotebookLM for knowledge management and AI dictation like Whisper.

In this episode of Innovations in Clinical Implementation, recorded live at LongevityFest 2025, hosts Laurie Hofmann and Dr. Lexi Gonzales explore one of the most pressing challenges in metabolic and weight care: how to support meaningful weight loss without compromising lean muscle mass.
They are joined by Dr. Myles Spar, a double board-certified physician specializing in integrative internal medicine, and Dr. Edward Walker, researcher at New Zealand’s Plant and Food Research and lead scientist behind Amarasate, the bitter hops extract at the center of Calocurb’s appetite control formula.
Together, they discuss how triple satiety hormone activation may offer practitioners a valuable tool for supporting metabolic health, preserving muscle, and improving continuity of care before, during, and after GLP-1 therapy. The conversation also covers body composition monitoring, dosing considerations, endogenous GLP-1 support, and how Calocurb Clinical may fit into more comprehensive, lifestyle-forward care models.