Neuropsychiatric and neurodegenerative disorders are at an all-time high and one of the leading causes of disability worldwide. This Neurology module details the neuropsychological components of a systems biology approach to the brain and peripheral nervous systems. For example, recent developments in psychoneuroimmunology and the Gut-Neuro-Endocrine axis have defined the critical relationships between the brain and all bodily systems at the cellular and sub-cellular levels. The role of neuroinflammation and its relation to microbes, metals and other exposures on brain health will also be explored. Cutting edge treatments such as lipid therapy, the Bredesen Protocol, hyperbaric oxygen treatment, peptides, nutritional approaches, and regenerative therapies will be covered.