Annelie Smith, RD (SA), IFNCP

Annelie Smith, RD (SA), IFNCP, is Head of Clinical, Health Impact & Integration at 3X4 Genetics and a senior clinician specializing in clinical nutrigenomics and translational genetics. She brings over 25 years of clinical experience and more than two decades focused on applying genomic science to personalized, preventive, and longevity-oriented healthcare. Her work is grounded in systems biology and centers on leveraging genetic insights to inform targeted interventions across key aging and disease-modifying pathways, including metabolic function, inflammation, hormonal regulation, and cellular resilience.

Annelie holds a Bachelor of Science in Dietetics and a Bachelor of Science (Medical) Honors in Clinical Nutrition from the University of Cape Town and is a registered dietitian with the Health Professions Council of South Africa (HPCSA). She has completed advanced training in sports nutrition, integrative and functional nutrition, and translational genetics, including certification as an Integrative and Functional Nutrition Certified Practitioner (IFNCP).

At 3X4 Genetics, Annelie provides scientific and clinical leadership across practitioner education, clinical framework development, and product innovation, ensuring genomic applications are evidence-informed, clinically robust, and outcomes-driven. She has been instrumental in the development of widely adopted practitioner resources, including the 3X4 Genetics Blueprint and the 3X4 Clinical Guide, which support functional and integrative clinicians in translating genetic data into actionable strategies for disease risk modification, health optimization, and healthy aging.

Her clinical background spans performance nutrition, executive wellness, lifestyle-related disease prevention, and critical care nutrition. She has guided thousands of patients and mentored healthcare professionals internationally through case-based education focused on precision nutrition, prevention science, and the integration of genomics into longevity medicine.