Module I: The Basic Principles of Stem Cells

Upon completion of the module, the participant will:

  • Understand the basics of stem cells
    • Understand the basics of stem cells
      • Embryonic germ cells
      • Embryonic germ cells
      • Differentiated stem cell types from embryonic stem cells
        • ECTODERM: Neuroprogenitors
        • MESODERM: Cardiomyocytes, hematopoietic progenitors, leucocytes, endothelial cells
        • ENDODERM: Insulin positive cells, hepatocyte-like cells
  • Understand the principles of stem cells
    • Development of embryonic stem cells
      • Self renewal
      • Differentiation
      • Totipotency
      • Pluripotency
      • Multipotency
      • Committed progenitors
      • Terminal differentiation
      • Stem cell pasticity or transdifferentiation
    • Understand the concepts of
      • Stem cell niches in bone marrow
        • Osteoblastic
        • Vascular
      • Stem cell niches in other organs, e.g. neural, cardiac, skeletal
      • Trafficking of stem cells
      • Mobilization of stem cells
      • Phenotypic differentiation of stem cells
  • Understand principles of
    • Adult stem cells
      • Blood: Hematopoietic stem cells (HPC), endothelial stem cells (EPC)
      • Bone marrow: Hematopoietic stem cells, endothelial progenitor cells, mesenchymal stem cells.
      • Brain
      • Fat
      • Liver
      • Muscle
      • Pancreas
      • Umbilical cord
      • Fetal derived cells- amniotic fluid, chorionic villi, placental
    • Induced pluripotent stem cells
      • Autologous cell transplantation
      • Allogeneic cell transplantation
      • Issues of immune compatibility
      • Regeneration of tissues
      • Development of new cellular therapies
  • Will be introduced to principles of regenerative medicine - current and future perspectives
    • Rationale of cell based therapies
    • Autologous cell based therapies
    • Allogeneic cell therapies
    • Immunosuppressive properties of mesenchymal stem cells
    • Commercialization of cell therapy
    • Current issues in stem cell based therapies
    • Basics of cell therapy applications for:
      • Neural
      • Cardiovascular
      • Orthopedic
      • Metabolic and secretory
      • Hematopoietic and autoimmune